Description
ACVR2B (ACE-031)
Activin Receptor Type II B
Description
Ace-031, also known as ACVR2B, is a soluble form of activin type IIB receptor,
which is an inhibitor of myostatin and other naturally occurring proteins that limit
muscle growth. This compound was genetically developed to bind to myostatin
before it can attach to its receptor and halt muscle growth. The two Biopharma
companies that worked on this compound are Acceleron and Shire.
Ace-031 is a sterile, non-pyrogenic, white lyophilized powder intended for
subcutaneous or intramuscular injection, after reconstitution with sterile Water for
Injection.
Mechanism of Action
ACE-031 is a protein that’s being investigated to determine if it can be used for
therapeutic purpose for building muscle and enhancing the strength of test
subjects. It does this by allowing molecules to bind to cell surface receptors — this is
also where it signals through. These cell surface receptors are known as Activin
Receptor Type II B. ACE-031 is recombinant fusion protein that is produced when a
portion of the ACVR2B receptor and a part of the standard antibody are joined
together. This then creates a decoy version of ACVR2B that circulates and
eliminates proteins like GDF-8 (also known as myostatin) and other molecules
that limits the muscle’s strength of growth.
The proteins in the TGF-8 superfamily are used to regulate muscle growth. These
act as the on and off switch for the production of muscles. In order to stop muscle
growth , several molecules, such as GDF-8, intermingle with the ACVR2B receptor,
which stops the production of muscle. When these off switches aren’t present, the
muscle increases in mass radically.
Adverse reactions
ACE-031 could have the following side effects:
- Water Retention
- Bleeding from the nose
- Increased Hunger
- Headache
- Reactions at injection site
Instructions for reconstitution
Flip off the top of the peptide vial with your thumb. Use the alcohol swab to wipe the
rubber stopper of the peptide vial. Push the needle of the syringe into the middle of the
rubber stopper so it goes through the rubber and into the vial. Now, while angling the
needle so that the water for injection goes down the side of the glass, rather than
directly into the powder, inject the water for injection into the vial. Repeat this step until
you have the correct amount of water in the vial. The powder will dissolve quickly,
however it can help to gently roll the vial in between your fingers (do not shake the vial
vigorously). Remove the syringe and dispose of it. You should never reuse a syringe.
Dosage
Recommended dosage of ACE-031:
- 500 — 1.000 mcg twice a week
Storage
- After reconstitution, may be stored for a maximum of 14 days in a refrigerator at 2°C — 8°C.
- Store vials in an upright position.
- Store in a refrigerator (2°C — 8°C). Keep in the outer carton in order to protect from light.
- For one month can be stored at room temperature.
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